Network medicine analysis of chondrocyte proteins towards new treatments of osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a progressive disorder with high incidence in the ageing human population that still has no treatment currently. This disorder induces the breakdown of articular cartilage, leading to the exposure and damage of bone surfaces. For a global understanding of OA development, the systematic integration of known OA-related proteins with protein-protein interaction (PPI) networks is required. In this work, the OA-related interactome was reconstructed using multiple data sources to have the most up-to-date information on OA-related proteins and their interactions. We then combined emergent concepts in network medicine to detect new unclassified OA-related proteins. The mapping of known OA-related proteins with PPI networks showed that these proteins are locally connected to

SUBMITTER: Nacher JC 

PROVIDER: S-EPMC3906943 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature