Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors.

ABSTRACT: Chronic pressure-overload cardiac hypertrophy is associated with an increased risk of morbidity/mortality, largely due to maladaptive remodeling and dilatation that progresses to dilated cardiomyopathy. Alternative splicing is an important biological mechanism that generates proteomic complexity and diversity. The recent development of next-generation RNA sequencing has improved our understanding of the qualitative signatures associated with alternative splicing in various biological conditions. However, the role of alternative splicing in cardiac hypertrophy is yet unknown. The present study employed RNA-Seq and a bioinformatic approach to detect the RNA splicing regulatory elements involved in alternative splicing during pressure-overload cardiac hypertrophy. We found GC-rich exonic moti

SUBMITTER: Kim T 

PROVIDER: S-EPMC3907004 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature