Systematic genomic identification of colorectal cancer genes delineating advanced from early clinical stage and metastasis.

ABSTRACT:

Background

Colorectal cancer is the third leading cause of cancer deaths in the United States. The initial assessment of colorectal cancer involves clinical staging that takes into account the extent of primary tumor invasion, determining the number of lymph nodes with metastatic cancer and the identification of metastatic sites in other organs. Advanced clinical stage indicates metastatic cancer, either in regional lymph nodes or in distant organs. While the genomic and genetic basis of colorectal cancer has been elucidated to some degree, less is known about the identity of specific cancer genes that are associated with advanced clinical stage and metastasis.

Methods

We compiled multiple genomic data types (mutations, copy number alterations, gene expression and methylatio

SUBMITTER: Lee H 

PROVIDER: S-EPMC3907018 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature