Highway proximity associated with cardiovascular disease risk: the influence of individual-level confounders and exposure misclassification.

ABSTRACT:

Background

Elevated cardiovascular disease risk has been reported with proximity to highways or busy roadways, but proximity measures can be challenging to interpret given potential confounders and exposure error.

Methods

We conducted a cross sectional analysis of plasma levels of C-Reactive Protein (hsCRP), Interleukin-6 (IL-6), Tumor Necrosis Factor alpha receptor II (TNF-RII) and fibrinogen with distance of residence to a highway in and around Boston, Massachusetts. Distance was assigned using ortho-photo corrected parcel matching, as well as less precise approaches such as simple parcel matching and geocoding addresses to street networks. We used a combined random and convenience sample of 260 adults >40 years old. We screened a large number of individual-level variables

SUBMITTER: Brugge D 

PROVIDER: S-EPMC3907023 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature