Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer.

ABSTRACT:

Background

Reciprocal interactions between lung mesenchymal and epithelial cells play essential roles in lung organogenesis and homeostasis. Although the molecular markers and related animal models that target lung epithelial cells are relatively well studied, molecular markers of lung mesenchymal cells and the genetic tools to target and/or manipulate gene expression in a lung mesenchyme-specific manner are not available, which becomes a critical barrier to the study of lung mesenchymal biology and the related pulmonary diseases.

Results

We have identified a mouse Tbx4 gene enhancer that contains conserved DNA sequences across many vertebrate species with lung or lung-like gas exchange organ. We then generate a mouse line to express rtTA/LacZ under the control of the Tbx4 l

SUBMITTER: Zhang W 

PROVIDER: S-EPMC3907025 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature