'Escaping' the X chromosome leads to increased gene expression in the male germline of Drosophila melanogaster.

ABSTRACT: Genomic analyses of Drosophila species suggest that the X chromosome presents an unfavourable environment for the expression of genes in the male germline. A previous study in D. melanogaster used a reporter gene driven by a testis-specific promoter to show that expression was greatly reduced when the gene was inserted onto the X chromosome as compared with the autosomes. However, a limitation of this study was that only the expression regulated by a single, autosomal-derived promoter was investigated. To test for an increase in expression associated with 'escaping' the X chromosome, we analysed reporter gene expression driven by the promoters of three X-linked, testis-expressed genes (CG10920, CG12681 and CG1314) that were inserted randomly throughout the D. melanogaster genome. In all ca

SUBMITTER: Kemkemer C 

PROVIDER: S-EPMC3907100 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature