Estimation of retinal ganglion cell loss in glaucomatous eyes with a relative afferent pupillary defect.

ABSTRACT:

Purpose

To estimate retinal ganglion cell (RGC) losses associated with a relative afferent pupillary defect (RAPD) in glaucoma.

Methods

A cross-sectional study was conducted including both eyes of 103 participants from the Diagnostic Innovations in Glaucoma Study. A total of 77 subjects had glaucoma in at least one eye and 26 were healthy. Pupil responses were assessed using an automated pupillometer that records the magnitude of RAPD as an "RAPD score." Standard automated perimetry (SAP) and optical coherence tomography (OCT) also were performed. Retinal ganglion cell counts were estimated using empirical formulas that combine estimates from SAP and OCT. The estimated percentage RGC loss was calculated using the combined structure function index (CSFI).

Results

There

SUBMITTER: Tatham AJ 

PROVIDER: S-EPMC3907131 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature