Cutting the wires: modularization of cellular networks for experimental design.

ABSTRACT: Understanding naturally evolved cellular networks requires the consecutive identification and revision of the interactions between relevant molecular species. In this process, initially often simplified and incomplete networks are extended by integrating new reactions or whole subnetworks to increase consistency between model predictions and new measurement data. However, increased consistency with experimental data alone is not sufficient to show the existence of biomolecular interactions, because the interplay of different potential extensions might lead to overall similar dynamics. Here, we present a graph-based modularization approach to facilitate the design of experiments targeted at independently validating the existence of several potential network extensions. Our method is based o

SUBMITTER: Lang M 

PROVIDER: S-EPMC3907224 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature