Delays induce novel stochastic effects in negative feedback gene circuits.

ABSTRACT: Stochastic models of reaction networks are widely used to depict gene expression dynamics. However, stochastic does not necessarily imply accurate, as subtle assumptions can yield erroneous results, masking key discrete effects. For instance, transcription and translation are not instantaneous processes-explicit delays separate their initiation from the appearance of their functional products. However, delays are often ignored in stochastic, single-gene expression models. By consequence, effects such as delay-induced stochastic oscillations at the single-cell level have remained relatively unexplored. Here, we present a systematic study of periodicity and multimodality in a simple gene circuit with negative feedback, analyzing the influence of negative feedback strength and transcriptional

SUBMITTER: Zavala E 

PROVIDER: S-EPMC3907244 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature