Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.

ABSTRACT: Deregulation of the translational machinery is emerging as a critical contributor to cancer development. The contribution of microRNAs in translational gene control has been established however; the role of microRNAs in disrupting the cap-dependent translation regulation complex has not been previously described. Here, we established that elevated miR-520c-3p represses global translation, cell proliferation and initiates premature senescence in HeLa and DLBCL cells. Moreover, we demonstrate that miR-520c-3p directly targets translation initiation factor, eIF4GII mRNA and negatively regulates eIF4GII protein synthesis. miR-520c-3p overexpression diminishes cells colony formation and reduces tumor growth in a human xenograft mouse model. Consequently, downregulation of eIF4GII by siRNA decre

SUBMITTER: Mazan-Mamczarz K 

PROVIDER: S-EPMC3907297 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature