Seizure control of current shunt on rats with temporal lobe epilepsy and neocortical epilepsy.

ABSTRACT:

Purpose

To examine the effects of current shunt on rats with temporal lobe epilepsy and neocortex epilepsy.

Experimental design

A kainic acid (KA)-induced model of temporal lobe seizure and a penicillin-induced model of neocortical partial seizure were used in this study. Rats of each model were randomly allocated into two groups: control and model groups. The model group was further divided into the KA or penicillin group, sham conduction group and conduction group. The current shunt was realized through the implantation of a customized conduction electrode. After surgery, electroencephalogram (EEG) was recorded for two hours for each rat under anesthesia. Subsequently, the rats were video monitored for 72 h to detect the occurrence of behavioral seizures upon awakening. Th

SUBMITTER: Zhang L 

PROVIDER: S-EPMC3907408 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature