Ontology highlight
ABSTRACT:
SUBMITTER: Rolin O
PROVIDER: S-EPMC3907416 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Rolin Olivier O Smallridge Will W Henry Michael M Goodfield Laura L Place David D Harvill Eric T ET
PloS one 20140130 1
Transmission of pathogens has been notoriously difficult to study under laboratory conditions leaving knowledge gaps regarding how bacterial factors and host immune components affect the spread of infections between hosts. We describe the development of a mouse model of transmission of a natural pathogen, Bordetella bronchiseptica, and its use to assess the impact of host immune functions. Although B. bronchiseptica transmits poorly between wild-type mice and mice lacking other immune components ...[more]