Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.

ABSTRACT: The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computation

SUBMITTER: Havelka D 

PROVIDER: S-EPMC3907432 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature