Improved quantification precision of human brain short echo-time (1) H magnetic resonance spectroscopy at high magnetic field: a simulation study.

ABSTRACT:

Purpose

The gain in quantification precision that can be expected in human brain (1) H MRS at very high field remains a matter of debate. Here, we investigate this issue using Monte-Carlo simulations.

Methods

Simulated human brain-like (1) H spectra were fitted repeatedly with different noise realizations using LCModel at B0 ranging from 1.5T to 11.7T, assuming a linear increase in signal-to-noise ratio with B0 in the time domain, and assuming a linear increase in linewidth with B0 based on experimental measurements. Average quantification precision (Cramér-Rao lower bound) was then determined for each metabolite as a function of B0 .

Results

For singlets, Cramér-Rao lower bounds improved (decreased) by a factor of ∼ B0 as B0 increased, as predicted by theory. For mos

SUBMITTER: Deelchand DK 

PROVIDER: S-EPMC3907456 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature