A simple method for the electrophilic cyanation of secondary amines.

ABSTRACT: Bleach oxidizes trimethylsilyl cyanide to generate an electrophilic cyanating reagent that readily reacts with an amine nucleophile. This oxidative N-cyanation reaction allows for the preparation of disubstituted cyanamides from amines without using highly toxic cyanogen halides.

SUBMITTER: Zhu C 

PROVIDER: S-EPMC3907775 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature