The role of electrostatic energy in prediction of obligate protein-protein interactions.

ABSTRACT:

Background

Prediction and analysis of protein-protein interactions (PPI) and specifically types of PPIs is an important problem in life science research because of the fundamental roles of PPIs in many biological processes in living cells. In addition, electrostatic interactions are important in understanding inter-molecular interactions, since they are long-range, and because of their influence in charged molecules. This is the main motivation for using electrostatic energy for prediction of PPI types.

Results

We propose a prediction model to analyze protein interaction types, namely obligate and non-obligate, using electrostatic energy values as properties. The prediction approach uses electrostatic energy values for pairs of atoms and amino acids present in interfaces whe

SUBMITTER: Maleki M 

PROVIDER: S-EPMC3907787 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature