Analysis of the rs10046 polymorphism of aromatase (CYP19) in premenopausal onset of human breast cancer.

ABSTRACT: The CYP19 gene encodes aromatase, an enzyme catalyzing the conversion of androgens to estrogens. Studies analyzing associations between single nucleotide polymorphisms in CYP19 and breast cancer risk have shown inconsistent results. The rs10046 polymorphism is located in the 3' untranslated region of the CYP19 gene, but the influence of this polymorphism on breast cancer risk is unclear. In this study, we investigated the impact of rs10046 SNP on breast cancer risk, age at onset and association with clinical characteristics in an Austrian population of 274 breast cancer patients and 253 controls. The results show that a significantly increased fraction of patients with the TT genotype of rs10046 develop breast cancer under the age of 50 (41.8% of TT patients, compared to 26.6% of C carrier

SUBMITTER: Zins K 

PROVIDER: S-EPMC3907833 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature