Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma.

ABSTRACT: Testicular germ cell tumors (TGCTs) are the most common solid cancers in young men, with an increasing incidence over several years. However, their pathogenesis remains a matter of debate. Some epidemiological data suggest the involvement of both environmental and genetic factors. We reported two distinct effects of estrogens and/or xeno-estrogens on in vitro human seminoma-derived cells proliferation: (1) an antiproliferative effect via a classical estrogen receptor beta-dependent pathway, and (2) a promotive effect via a non-classical membrane G-protein-coupled receptor, GPR30/GPER, which is only overexpressed in seminomas, the most common TGCT. In order to explain this overexpression, we investigated the possible association of polymorphisms in the GPER gene by using allele-specific tet

SUBMITTER: Chevalier N 

PROVIDER: S-EPMC3907887 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature