Sodium valproate use is associated with reduced parietal lobe thickness and brain volume.

ABSTRACT:

Objective

We hypothesized that total brain volume, white matter volume, and lobar cortical thickness would be different in epilepsy patients. We studied valproate relative to nonvalproate by using patients with epilepsy and healthy controls.

Methods

Patients with focal intractable epilepsy from a tertiary epilepsy center were the primary group for analysis. A confirmatory analysis was carried out in an independent group of subjects imaged as part of a community-based study of childhood-onset epilepsy. Total brain volume; white matter volume; and frontal, parietal, occipital, and temporal lobe thickness were measured by processing whole-brain T1-weighted MRI using FreeSurfer 5.1.

Results

Total brain volume, white matter volume, and parietal thickness were reduced in th

SUBMITTER: Pardoe HR 

PROVIDER: S-EPMC3908352 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature