Cerebellar learning distinguishes inflammatory neuropathy with and without tremor.

ABSTRACT:

Objectives

This study aims to investigate if patients with inflammatory neuropathies and tremor have evidence of dysfunction in the cerebellum and interactions in sensorimotor cortex compared to nontremulous patients and healthy controls.

Methods

A prospective data collection study investigating patients with inflammatory neuropathy and tremor, patients with inflammatory neuropathy without tremor, and healthy controls on a test of cerebellar associative learning (eyeblink classical conditioning), a test of sensorimotor integration (short afferent inhibition), and a test of associative plasticity (paired associative stimulation). We also recorded tremor in the arms using accelerometry and surface EMG.

Results

We found impaired responses to eyeblink classical conditioni

SUBMITTER: Schwingenschuh P 

PROVIDER: S-EPMC3908356 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature