Risk factors for dementia with Lewy bodies: a case-control study.

ABSTRACT:

Objective

To determine the risk factors associated with dementia with Lewy bodies (DLB).

Methods

We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort.

Results

Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p < 0.0001), depression (6.0; 3.7-9.5; p < 0.0001), stroke (2.8; 1.3-6.3; p = 0.01), a family history of Parkinson disease (PD) (4.6; 2.5-8.6; p < 0.0001), and carry APOE ε4 alleles (2.2; 1.5-3.3; p < 0.0001), but less likely to have had cancer (0.44; 0.27-

SUBMITTER: Boot BP 

PROVIDER: S-EPMC3908463 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature