A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.

ABSTRACT:

Objective

Lithium remains a first-line treatment for bipolar disorder, but the mechanisms by which it prevents the recurrence of mood episodes are not known. The authors utilized data from a genomewide association study to examine associations between single nucleotide polymorphisms (SNPs) and the outcome of lithium treatment in two cohorts of patients with bipolar I disorder or bipolar II disorder.

Method

The hazard for mood episode recurrence was examined among 1,177 patients with bipolar I disorder or bipolar II disorder, including 458 individuals treated with lithium carbonate or citrate, who were participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) cohort. SNPs showing the greatest evidence of association in Cox regression models w

SUBMITTER: Perlis RH 

PROVIDER: S-EPMC3908470 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature