An effective evolutionary algorithm for protein folding on 3D FCC HP model by lattice rotation and generalized move sets.

ABSTRACT:

Background

Proteins are essential biological molecules which play vital roles in nearly all biological processes. It is the tertiary structure of a protein that determines its functions. Therefore the prediction of a protein's tertiary structure based on its primary amino acid sequence has long been the most important and challenging subject in biochemistry, molecular biology and biophysics. In the past, the HP lattice model was one of the ab initio methods that many researchers used to forecast the protein structure. Although these kinds of simplified methods could not achieve high resolution, they provided a macrocosm-optimized protein structure. The model has been employed to investigate general principles of protein folding, and plays an important role in the prediction of prot

SUBMITTER: Tsay JJ 

PROVIDER: S-EPMC3908773 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature