Ontology highlight
ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC3908839 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Developmental cell 20131201 5
Epithelial-mesenchymal transition (EMT) is an important developmental process hijacked by cancer cells for their dissemination. Here, we show that Exo70, a component of the exocyst complex, undergoes isoform switching mediated by ESRP1, a pre-mRNA splicing factor that regulates EMT. Expression of the epithelial isoform of Exo70 affects the levels of key EMT transcriptional regulators such as Snail and ZEB2 and is sufficient to drive the transition to epithelial phenotypes. Differential Exo70 iso ...[more]