Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index.

ABSTRACT: Whole genome pathway analysis is a powerful tool for the exploration of the combined effects of gene-sets within biological pathways. This study applied Interval Based Enrichment Analysis (INRICH) to perform whole-genome pathway analysis of body-mass index (BMI). We used a discovery set composed of summary statistics from a meta-analysis of 123,865 subjects performed by the GIANT Consortium, and an independent sample of 8,632 subjects to assess replication of significant pathways. We examined SNPs within nominally significant pathways using linear mixed models to estimate their contribution to overall BMI heritability. Six pathways replicated as having significant enrichment for association after correcting for multiple testing, including the previously unknown relationships between BMI an

SUBMITTER: Simonson MA 

PROVIDER: S-EPMC3908858 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature