Atrial fibrillation alters the microRNA expression profiles of the left atria of patients with mitral stenosis.

ABSTRACT:

Background

Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, and alterations in microRNA (miRNA) expression profiles of the right atria have also been investigated. However, miRNA changes in the left atria still require delineation. This study evaluated alterations in miRNA expression profiles of left atrial tissues from MS patients with AF relative to those with normal sinus rhythm (NSR).

Methods

Sample tissues from left atrial appendages were obtained from 12 MS patients (6 with AF) during mitral valve replacement surgery. From these tissues, miRNA expression profiles were created and analyzed using a human miRNA microarray. Results were validated via reverse-transcription and quantitati

SUBMITTER: Liu H 

PROVIDER: S-EPMC3909014 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature