Genetic association analysis of 30 genes related to obesity in a European American population.

ABSTRACT:

Objective

Obesity, which is frequently associated with diabetes, hypertension and cardiovascular diseases, is primarily the result of a net excess of caloric intake over energy expenditure. Human obesity is highly heritable, but the specific genes mediating susceptibility in non-syndromic obesity remain unclear. We tested candidate genes in pathways related to food intake and energy expenditure for association with body mass index (BMI).

Methods

We reanalyzed 355 common genetic variants of 30 candidate genes in seven molecular pathways related to obesity in 1982 unrelated European Americans from the New York Cancer Project. Data were analyzed by using a Bayesian hierarchical generalized linear model. The BMIs were log-transformed and then adjusted for covariates, including a

SUBMITTER: Li P 

PROVIDER: S-EPMC3909018 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature