Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia.

ABSTRACT:

Background

Despite the advances in our understanding of aging-associated behavioral decline, relatively little is known about how aging affects neural circuits that regulate specific behaviors, particularly the expression of genes in specific neural circuits during aging. We have addressed this by exploring a peptidergic neuron R15, an identified neuron of the marine snail Aplysia californica. R15 is implicated in reproduction and osmoregulation and responds to neurotransmitters such as acetylcholine, serotonin and glutamate and is characterized by its action potential bursts.

Results

We examined changes in gene expression in R15 neurons during aging by microarray analyses of RNAs from two different age groups, mature and old animals. Specifically we find that 1083 ESTs are

SUBMITTER: Kadakkuzha BM 

PROVIDER: S-EPMC3909179 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature