Clinical outcome of hypofractionated breath-hold image-guided SABR of primary lung tumors and lung metastases.

ABSTRACT:

Background

Stereotactic Ablative RadioTherapy (SABR) of lung tumors/metastases has been shown to be an effective treatment modality with low toxicity. Outcome and toxicity were retrospectively evaluated in a unique single-institution cohort treated with intensity-modulated image-guided breath-hold SABR (igSABR) without external immobilization. The dose-response relationship is analyzed based on Biologically Equivalent Dose (BED).

Patients and methods

50 lesions in 43 patients with primary NSCLC (n = 27) or lung-metastases of various primaries (n = 16) were consecutively treated with igSABR with Active-Breathing-Coordinator (ABC®) and repeat-breath-hold cone-beam-CT. After an initial dose-finding/-escalation period, 5 x 12 Gy for peripheral lesions and single doses of 5 Gy to

SUBMITTER: Boda-Heggemann J 

PROVIDER: S-EPMC3909294 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature