RNA profiling reveals familial aggregation of molecular subtypes in non-BRCA1/2 breast cancer families.

ABSTRACT:

Background

In more than 70% of families with a strong history of breast and ovarian cancers, pathogenic mutation in BRCA1 or BRCA2 cannot be identified, even though hereditary factors are expected to be involved. It has been proposed that tumors with similar molecular phenotypes also share similar underlying pathophysiological mechanisms. In the current study, the aim was to investigate if global RNA profiling can be used to identify functional subgroups within breast tumors from families tested negative for BRCA1/2 germline mutations and how these subgroupings relate to different breast cancer patients within the same family.

Methods

In the current study we analyzed a collection of 70 frozen breast tumor biopsies from a total of 58 families by global RNA profiling and promo

SUBMITTER: Larsen MJ 

PROVIDER: S-EPMC3909442 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature