Integrated analysis of the Wnt responsive proteome in human cells reveals diverse and cell-type specific networks.

ABSTRACT: Wnt signalling is a fundamentally important signalling pathway that regulates many aspects of metazoan development and is frequently dysregulated in cancer. Although many of the core components of the Wnt signalling pathway, such as β-catenin, have been extensively studied, the broad systems level responses of the mammalian cell to Wnt signalling are less well understood. In addition, the cell- or tissue-specific protein networks that modulate Wnt signalling in the diverse tissues or developmental stages in which it functions remain to be defined. To address these questions, we undertook a broad survey of the Wnt response in different human cell lines using both interaction and expression proteomics approaches. Our data reveal both similar and divergent responses of pathways and processes

SUBMITTER: Song J 

PROVIDER: S-EPMC3909504 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature