Ontology highlight
ABSTRACT:
SUBMITTER: Lejmi E
PROVIDER: S-EPMC3909532 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Lejmi Esma E Bouras Ilyes I Camelo Serge S Roumieux Marie M Minet Norbert N Leré-Déan Carole C Merkulova-Rainon Tatyana T Autret Gwennhael G Vayssettes Catherine C Clement Olivier O Plouët Jean J Leconte Laurence L
Vascular cell 20140128 1
Netrins are secreted molecules involved in axon guidance and angiogenesis. We previously showed that Netrin-4 acts as an anti-angiogenic factor by inhibiting endothelial cell (EC) functions. In this study, we investigated the effects of Netrin-4 on vascular smooth muscle cell (VSMC) activity in vitro and in vivo. We show that exogenous Netrin-4 stimulated VSMC adhesion and migration, and increased their coverage on EC tubes (grown on a Matrigel substrate). siRNA knock-down of endogenous Netrin-4 ...[more]