Dynamics and activation in response regulators: the β4-α4 loop.

ABSTRACT: Two-component signal transduction systems of microbes are a primary means to respond to signals emanating from environmental and metabolic fluctuations as well as to signals coordinating the cell cycle with macromolecular syntheses, among a large variety of other essential roles. Signals are recognized by a sensor domain of a histidine kinase which serves to convert signal binding to an active transmissible phosphoryl group through a signal-induced ATP-dependent autophosphorylation reaction directed to histidine residue. The sensor kinase is specifically mated to a response regulator, to which it transfers the phosphoryl group that activates the response regulator's function, most commonly gene repression or activation but also interaction with other regulatory proteins. Two-component syst

SUBMITTER: Bobay BG 

PROVIDER: S-EPMC3909562 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature