Expanding role of T cells in acute kidney injury.

ABSTRACT:

Purpose of review

Recent advances in T cell biology have shed light on the role of T cell subsets in the pathogenesis of acute kidney injury (AKI). The purpose of this review is to harness our understanding of recent advances in T cell biology in tissue injury and repair and provide a mechanistic insight into the role of T cells in the inflammation of AKI.

Recent findings

New specific reagents and genetic animal models have led to advances in our understanding of the role of T cell subsets involved in renal injury. Whereas some T cells promote innate renal inflammation and injury, other T cells promote protection and repair. Recent studies illuminated the pathogenic mechanisms of invariant natural killer T (NKT) cells and T helper1-type responses, and the beneficial function

SUBMITTER: Kinsey GR 

PROVIDER: S-EPMC3909711 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature