Renal vein cytokine release as an index of renal parenchymal inflammation in chronic experimental renal artery stenosis.

ABSTRACT:

Background

Renal parenchymal inflammation is a critical determinant of kidney injury in renal artery stenosis (RAS) but is difficult to assess in the single kidney without tissue samples. Whether renal vein (RV) levels of inflammatory markers reflect active parenchymal inflammation remains unknown. We evaluated the relationship between net RV cytokine release and tissue inflammation in the post-stenotic kidney.

Methods

Pigs were studied after 10 weeks of RAS treated 4 weeks earlier with intra-renal vehicle or anti-inflammatory mesenchymal stem cells (MSCs) or normal control. Single-kidney renal blood flow was measured by fast computerized tomography. RV and inferior vena cava levels of tumor necrosis factor (TNF)-α, interferon (IF)-γ, monocyte chemoattractant protein (MCP-1)

SUBMITTER: Eirin A 

PROVIDER: S-EPMC3910338 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature