Immunogenicity of murine solid tumor models as a defining feature of in vivo behavior and response to immunotherapy.

ABSTRACT: Immune profiling has been widely used to probe mechanisms of immune escape in cancer and identify novel targets for therapy. Two emerging uses of immune signatures are to identify likely responders to immunotherapy regimens among individuals with cancer and to understand the variable responses seen among subjects with cancer in immunotherapy trials. Here, the immune profiles of 6 murine solid tumor models (CT26, 4T1, MAD109, RENCA, LLC, and B16) were correlated to tumor regression and survival in response to 2 immunotherapy regimens. Comprehensive profiles for each model were generated using quantitative reverse transcriptase polymerase chain reaction, immunohistochemistry, and flow cytometry techniques, as well as functional studies of suppressor cell populations (regulatory T cells and m

SUBMITTER: Lechner MG 

PROVIDER: S-EPMC3910494 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature