Genome-wide association study identifies two susceptibility loci for osteosarcoma.

ABSTRACT: Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10??) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10?? and 2.9 × 10??, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.

SUBMITTER: Savage SA 

PROVIDER: S-EPMC3910497 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature