Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins.

ABSTRACT:

Objective

To determine whether statins affect type 1 interferon responses in relapsing-remitting multiple sclerosis (RRMS).

Design

Study effects of atorvastatin on type 1 interferon responses in Jurkat cells, mononuclear cells (MNCs) from therapy-naive patients with RRMS in vitro, and MNCs from interferon-treated RRMS patients in vivo in 4 conditions: no drug, statin only, interferon-beta only, and statin added on to interferon-beta therapy.

Patients

The study examined clinically stable patients with RRMS: 21 therapy-naive patients and 14 patients receiving interferon-beta with a statin.

Interventions

Statin effects on in vitro and in vivo interferon-beta-induced STAT1 transcription factor activation, expression of interferon-stimulated proteins in MNCs, and se

SUBMITTER: Feng X 

PROVIDER: S-EPMC3910505 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature