Dynamics of axonal regeneration in adult and aging zebrafish reveal the promoting effect of a first lesion.

ABSTRACT: Axonal regeneration is a major issue in the maintenance of adult nervous systems, both after nerve injuries and in neurodegenerative diseases. However, studying this process in vivo is difficult or even impossible in most vertebrates. Here we show that the posterior lateral line (PLL) of zebrafish is a suitable system to study axonal regeneration in vivo because of both the superficial location and reproducible spatial arrangement of neurons and targets, and the possibility of following reinnervation in live fish on a daily basis. Axonal regeneration after nerve cut has been demonstrated in this system during the first few days of life, leading to complete regeneration within 24 h. However, the potential for PLL nerve regeneration has not been tested yet beyond the early larval stage. We e

SUBMITTER: Graciarena M 

PROVIDER: S-EPMC3910642 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature