Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box.

ABSTRACT: Malaria remains a significant infectious disease that causes millions of clinical cases and >800,000 deaths per year. The Malaria Box is a collection of 400 commercially available chemical entities that have antimalarial activity. The collection contains 200 drug-like compounds, based on their oral absorption and the presence of known toxicophores, and 200 probe-like compounds, which are intended to represent a broad structural diversity. These compounds have confirmed activities against the asexual intraerythrocytic stages of Plasmodium falciparum and low cytotoxicities, but their mechanisms of action and their activities in other stages of the parasite's life cycle remain to be determined. The apicoplast is considered to be a promising source of malaria-specific targets, and its main fun

SUBMITTER: Bowman JD 

PROVIDER: S-EPMC3910863 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature