The Cryptococcus neoformans Rim101 transcription factor directly regulates genes required for adaptation to the host.

ABSTRACT: The Rim101 protein is a conserved pH-responsive transcription factor that mediates important interactions between several fungal pathogens and the infected host. In the human fungal pathogen Cryptococcus neoformans, the Rim101 protein retains conserved functions to allow the microorganism to respond to changes in pH and other host stresses. This coordinated cellular response enables this fungus to effectively evade the host immune response. Preliminary studies suggest that this conserved transcription factor is uniquely regulated in C. neoformans both by the canonical pH-sensing pathway and by the cyclic AMP (cAMP)/protein kinase A (PKA) pathway. Here we present comparative transcriptional data that demonstrate a strong concordance between the downstream effectors of PKA and Rim101. To def

SUBMITTER: O'Meara TR 

PROVIDER: S-EPMC3911494 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature