Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis.

ABSTRACT:

Background

The chemokine receptor CXCR4 plays a significant role in biological processes, as well as in tumorigenesis and the progression of cancer, especially breast cancer. However, the clinical application of CXCR4 for breast cancer prognosis is still very limited. A meta-analysis based on published studies was performed with the aim of obtaining an accurate evaluation of the relationship between CXCR4 expression and the prognosis of breast cancer.

Methods

A comprehensive search strategy was used to search relevant literature in PubMed, MEDLINE and the ISI Web of Science. The correlation between CXCR4 expression and clinicopathological features and breast cancer prognosis was analyzed. This meta-analysis was carried out using Review Manager 4.2.

Result

Thirteen eli

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC3911796 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature