Sensory neuron differentiation is regulated by notch signaling in the trigeminal placode.

ABSTRACT: Trigeminal sensory neurons develop from the neural crest and neurogenic placodes, and have been studied as a principal model of sensory neuron formation. While the Notch pathway has been extensively characterized in central nervous system development and other developmental processes, it has not been well characterized in sensory neurogenesis. Here we studied the functional role of Notch signaling in the trigeminal ophthalmic (opV) placode, a prime model of sensory neurogenesis. To establish a good spatiotemporal description of Notch pathway genes in the chick trigeminal placode, a stage-specific expression analysis was conducted, showing that expression of most Notch pathway genes and effectors are expressed in the placode, with expression primarily being confined to ectodermal cells. Exp

SUBMITTER: Lassiter RN 

PROVIDER: S-EPMC3911820 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature