Role of the stem cell-associated intermediate filament nestin in malignant proliferation of non-small cell lung cancer.

ABSTRACT:

Background

Nestin is associated with neoplastic transformation, but the mechanisms by which nestin contributes to invasion and malignancy of lung cancer remain unknown. Considering that proliferation is necessary for malignant behavior, we investigated the mechanism of nestin action in association with the proliferative properties of non-small cell lung cancer (NSCLC).

Methods

Nestin expression was examined in NSCLC specimens and cell lines. Associations with clinicopathological features, including prognosis and proliferative markers, were evaluated. Effects of nestin knockdown on proliferation and the signaling pathways involved were further investigated.

Results

Nestin was expressed in most cancer specimens and all the tumor cell lines analyzed. High nestin expressi

SUBMITTER: Chen Z 

PROVIDER: S-EPMC3911905 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature