BSA nanoparticle loaded atorvastatin calcium--a new facet for an old drug.

ABSTRACT:

Background

Currently, the discovery of effective chemotherapeutic agents poses a major challenge to the field of cancer biology. The present study focuses on enhancing the therapeutic and anti cancer properties of atorvastatin calcium loaded BSA (ATV-BSA) nanoparticles in vitro.

Methodology/results

BSA-ATV nanoparticles were prepared using desolvation technique. The process parameters were optimized based on the amount of desolvating agent, stabilization conditions as well as the concentration of the cross linker. The anti cancer properties of the protein coated ATV nanoparticles were tested on MiaPaCa-2 cell lines. In vitro release behavior of the drug from the carrier suggests that about 85% of the drug gets released after 72 hrs. Our studies show that ATV-BSA nanoparticle

SUBMITTER: Sripriyalakshmi S 

PROVIDER: S-EPMC3911917 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature