Increased prevalence of Methanosphaera stadtmanae in inflammatory bowel diseases.

ABSTRACT:

Background

The gut microbiota is associated with the modulation of mucosal immunity and the etiology of inflammatory bowel diseases (IBD). Previous studies focused on the impact of bacterial species on IBD but seldom suspected archaea, which can be a major constituent of intestinal microbiota, to be implicated in the diseases. Recent evidence supports that two main archaeal species found in the digestive system of humans, Methanobrevibacter smithii (MBS) and Methanosphaera stadtmanae (MSS) can have differential immunogenic properties in lungs of mice; with MSS but not MBS being a strong inducer of the inflammatory response. We thus aimed at documenting the immunogenic potential of MBS and MSS in humans and to explore their association with IBD.

Methods

To validate the immuno

SUBMITTER: Blais Lecours P 

PROVIDER: S-EPMC3912014 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature