Therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplantation in lymphoma patients.

ABSTRACT: Lymphoma patients treated with autologous transplantation (ASCT) live an increasingly long life with the recent advancement in therapeutic modalities. This has resulted in an increase in the incidence of therapy-related myeloid neoplasms (t-MN), which is one of the leading causes of non-relapse mortality. Several observational studies have linked the development of t-MN after ASCT with the intensity and frequency of chemotherapy, particularly alkylating agents, use of total body irradiation (TBI), and peripheral blood progenitor cells. In addition, role of genetic factors is increasingly being identified. It is postulated that the use of chemotherapy prior to ASCT results in DNA damage of progenitor cells, mitochondrial dysfunction, and altered gene expression related to DNA repair, metabo

SUBMITTER: Akhtari M 

PROVIDER: S-EPMC3912029 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature