Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior.

ABSTRACT:

Background

Leptin (LEP) is a hormone central for energy homeostasis and has been implicated in neurodevelopment. This adipokine is produced by the placenta and is epigenetically regulated by promoter DNA methylation. Recent evidence has suggested a role for LEP in behavioral development. In this study, we investigated associations between profiles of human newborn neurobehavior and placental LEP DNA methylation.

Methods

We determined LEP promoter methylation in 444 placental samples from healthy term infants and measured LEP gene expression in a random subset of these samples. Infant neurobehavior was assessed with the NICU Network Neurobehavioral Scales (NNNS) and we examined the relationship between LEP promoter methylation and profiles of infant neurobehavior derived from

SUBMITTER: Lesseur C 

PROVIDER: S-EPMC3912462 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature