Identification of germline transcriptional regulatory elements in Aedes aegypti.

ABSTRACT: The mosquito Aedes aegypti is the principal vector for the yellow fever and dengue viruses, and is also responsible for recent outbreaks of the alphavirus chikungunya. Vector control strategies utilizing engineered gene drive systems are being developed as a means of replacing wild, pathogen transmitting mosquitoes with individuals refractory to disease transmission, or bringing about population suppression. Several of these systems, including Medea, UD(MEL), and site-specific nucleases, which can be used to drive genes into populations or bring about population suppression, utilize transcriptional regulatory elements that drive germline-specific expression. Here we report the identification of multiple regulatory elements able to drive gene expression specifically in the female germline,

SUBMITTER: Akbari OS 

PROVIDER: S-EPMC3912481 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature