Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial.

ABSTRACT:

Importance

There are no known effective treatments for painful chemotherapy-induced peripheral neuropathy.

Objective

To determine the effect of duloxetine, 60 mg daily, on average pain severity.

Design, setting, and patients

Randomized, double-blind, placebo-controlled crossover trial at 8 National Cancer Institute (NCI)-funded cooperative research networks that enrolled 231 patients who were 25 years or older being treated at community and academic settings between April 2008 and March 2011. Study follow-up was completed July 2012. Stratified by chemotherapeutic drug and comorbid pain risk, patients were randomized to receive either duloxetine followed by placebo or placebo followed by duloxetine. Eligibility required that patients have grade 1 or higher sensory neur

SUBMITTER: Smith EM 

PROVIDER: S-EPMC3912515 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature